Metaanalysis vs large clinical trials: which should guide our management?

Peterson or our beliefs ? Should the precautionary principle guide our actions

service Email alerting top right corner of the article Receive free email alerts when new articles cite this article-sign up in the box at the

A paediatrician's guide to clinical trials units

To cite: Gale C, Juszczak E. Arch Dis Child Educ Pract Ed 2016;101:265–267. INTRODUCTION A clinical trial is a research study that prospectively assigns health-related interventions to people (or groups) typically using randomisation to evaluate the effects on health outcomes. Welldesigned, suitably powered, randomised, trials provide the most reliable evidence about the effectiveness (or not) ...

Next-Generation Sequencing to Guide Clinical Trials.

Rapidly accruing knowledge of the mutational landscape of malignant neoplasms, the increasing facility of massively parallel genomic sequencing, and the availability of drugs targeting many "driver" molecular abnormalities have spurred the oncologic community to consider how to use these new tools to improve cancer treatment. In order to assure that assignment of patients to a particular target...

Clinical trials of stroke therapy: which cells, which patients?

Staples vs subcuticular sutures for skin closure at cesarean delivery: a metaanalysis of randomized controlled trials.

Recently published randomized trials examining skin closure technique on postcesarean wound complications have produced conflicting results. We performed a metaanalysis of trials comparing staples and subcuticular sutures for skin closure at cesarean section (CS). Pooled outcome measures were calculated using random effects models. Primary outcomes were rates of wound dehiscence (separation) an...